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BETA STREP (GROUP B) ANTIGEN
Message"Submit only one specimen per test request form. State source.
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Test Code
18804
Alias/See Also
Beta-Strep (Group B) Antigen
CPT Codes
87802
Preferred Specimen
"Serum, urine (random), or cerebrospinal fluid (CSF)
1 mL serum, 5 mL urine, or 0.5 mL CSF
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1 mL serum, 5 mL urine, or 0.5 mL CSF
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Instructions
"Indicate source of specimen
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Transport Container
"Red-top tube or gel-barrier tube, plastic urine container, or sterile plastic (CSF) tube
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Transport Temperature
Refrigerated
Specimen Stability
Refrigerated
Methodology
"Latex agglutination (LA) "
Reference Range
"Negative
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Clinical Significance
"Aid in documentation of active beta streptococcal infection
Group B Streptococcus is currently one of the most significant human pathogens in the neonatal period. The most common mode of acquisition by the neonate is exposure to the maternal genital flora in utero through ruptured membranes or by contamination during passage through the birth canal. Rapid identification of group B Streptococcus carriers is important in management of premature rupture of the membranes because the effectiveness of intrapartum prophylactic ampicillin may be compromised by awaiting the results of conventional cultures. Infection is manifested in two major forms, early onset septicemic infection manifest in the first few days of life and late onset meningitis which occurs during the first few months of life.
Increased isolation of strains of group B Streptococcus resistant to erythromycin (9%) or intermediate susceptible clindamycin (9.5%) and cefoxitin (15.3%) have been reported. Nineteen percent exhibited a multiple antibiotic resistance pattern. Penicillinase production and resistance to ampicillin were not encountered in the particular series. Susceptibility testing may be useful in selecting alternate antibiotic regimens.
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Group B Streptococcus is currently one of the most significant human pathogens in the neonatal period. The most common mode of acquisition by the neonate is exposure to the maternal genital flora in utero through ruptured membranes or by contamination during passage through the birth canal. Rapid identification of group B Streptococcus carriers is important in management of premature rupture of the membranes because the effectiveness of intrapartum prophylactic ampicillin may be compromised by awaiting the results of conventional cultures. Infection is manifested in two major forms, early onset septicemic infection manifest in the first few days of life and late onset meningitis which occurs during the first few months of life.
Increased isolation of strains of group B Streptococcus resistant to erythromycin (9%) or intermediate susceptible clindamycin (9.5%) and cefoxitin (15.3%) have been reported. Nineteen percent exhibited a multiple antibiotic resistance pattern. Penicillinase production and resistance to ampicillin were not encountered in the particular series. Susceptibility testing may be useful in selecting alternate antibiotic regimens.
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