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CRYOGLOBULIN, QL, SERUM, RFLX
Message"If reflex testing is performed, additional charges/CPT code(s) may apply
Patient should be fasting
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Patient should be fasting
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Test Code
1594
CPT Codes
82595
Includes
"Qualitative test for cryoglobulin; reflex quantitation (as percentage) and immunofixation of cryoprecipitate if positive
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Preferred Specimen
"Serum
4 mL
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4 mL
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Minimum Volume
"3 mL
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Instructions
"Specimen must be drawn in a prewarmed tube and kept at 37°C while clotting. Separate serum from cells immediately after clot formation (keep at 37°C while clotting) and transfer serum into a clean transport tube.
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Transport Container
"Red-top tube or gel-barrier tube
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Transport Temperature
room temp
Specimen Stability
room temp
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
"Specimen not allowed to clot at 37°C; patient not fasting; lipemia
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Methodology
"Visual observation of refrigerated samples "
Reference Range
"None detected (positives are reported as percentages)
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Clinical Significance
"Cryoglobulins may be present in macroglobulinemia of Waldenström, myeloma, chronic lymphocytic leukemia, lupus, chronic active hepatitis, and other viral infections.
These are proteins which precipitate from blood at low temperatures. A precipitate from serum which forms overnight at 4°C and dissolves at 37°C is called a cryoglobulin.
Cryoglobulins may be divided into three classes. Type I are monoclonal immunoglobulins and are usually associated with lymphoproliferative disorders. Type II are mixtures of a monoclonal IgM and polyclonal IgG, and are associated with macroglobulinemia and chronic active hepatitis. Type III are mixtures of polyclonal IgM and polyclonal IgG. These are found in a wide variety of disorders.
A high percentage of patients with cryoglobulinemia have clinical symptoms, and of these the most common are vascular (ie, purpura and digital necrosis). Raynaud phenomenon is also common.
Patients with SLE who are rheumatoid factor negative but cryoglobulin positive are more likely to develop renal disease than those who are rheumatoid factor positive and cryoglobulin negative.
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These are proteins which precipitate from blood at low temperatures. A precipitate from serum which forms overnight at 4°C and dissolves at 37°C is called a cryoglobulin.
Cryoglobulins may be divided into three classes. Type I are monoclonal immunoglobulins and are usually associated with lymphoproliferative disorders. Type II are mixtures of a monoclonal IgM and polyclonal IgG, and are associated with macroglobulinemia and chronic active hepatitis. Type III are mixtures of polyclonal IgM and polyclonal IgG. These are found in a wide variety of disorders.
A high percentage of patients with cryoglobulinemia have clinical symptoms, and of these the most common are vascular (ie, purpura and digital necrosis). Raynaud phenomenon is also common.
Patients with SLE who are rheumatoid factor negative but cryoglobulin positive are more likely to develop renal disease than those who are rheumatoid factor positive and cryoglobulin negative.
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