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ANTI-JO-1
Test Code161455
Alias/See Also
"Polymyositis
t-RNA Synthetase
"
t-RNA Synthetase
"
CPT Codes
86235
Includes
"Semiquantitative result of IgG class antibodies
"
"
Preferred Specimen
"Serum
0.6 mL
"
0.6 mL
"
Minimum Volume
0.3 mL
Transport Container
"Red-top tube or gel-barrier tube
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"
Transport Temperature
Room temp
Specimen Stability
"
Room temperature
14 days
Refrigerated
14 days
Frozen
14 days
Freeze/thaw cycles
Stable x3
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Room temperature
14 days
Refrigerated
14 days
Frozen
14 days
Freeze/thaw cycles
Stable x3
"
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
"Hemolysis; icterus; lipemia; bacterial contamination
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"
Methodology
"Multiplex flow immunoassay "
Reference Range
"0.0-0.9 AI
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"
Clinical Significance
"Evaluate patients suspected of having polymyositis, dermatomyositis, or polymyositis-scleroderma overlap syndrome
Anti-Jo-1 antibodies are present in approximately 20% to 30% of patients with adult-onset polymyositis syndromes. They are present in >65% of patients with both myositis and interstitial lung disease. In such patients, the presence of anti-Jo-1 antibodies may be predictive of a response to steroid treatment. Testing for ANAs is not adequate for the detection of anti-Jo-1 antibodies.
"
Anti-Jo-1 antibodies are present in approximately 20% to 30% of patients with adult-onset polymyositis syndromes. They are present in >65% of patients with both myositis and interstitial lung disease. In such patients, the presence of anti-Jo-1 antibodies may be predictive of a response to steroid treatment. Testing for ANAs is not adequate for the detection of anti-Jo-1 antibodies.
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