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HCV AB VERIFICATION
Message"This assay is offered to provide verification of a positive HCV antibody screen obtained using the Siemens Advia Centaur HCV assay or other reagent with comparable sensitivity and specificity. Because the verification methodology is Roche ECLIA, this assay cannot be used to verify an initial screen performed with the Roche methodology.
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Test Code
144075
Alias/See Also
"Hep C
Non A
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Non A
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CPT Codes
86804
Preferred Specimen
"Serum or plasma
1 mL
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1 mL
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Minimum Volume
"0.5 mL (Note: This volume does not allow for repeat testing.)
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Instructions
"If tube other than a gel-barrier tube is used, transfer separated serum or plasma to a plastic transport tube.
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Transport Container
"Red-top tube, gel-barrier tube, or lavender-top (EDTA) tube
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Transport Temperature
refrigerated
Specimen Stability
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Room temperature---4 days
Refrigerated---14 days
Frozen---14 days
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Room temperature---4 days
Refrigerated---14 days
Frozen---14 days
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Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
"Non-EDTA plasma specimen; PST gel-barrier tube
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Methodology
"Electrochemiluminescence (ECLIA) "
Limitations
"Testing for HCV antibodies is to assess past or present exposure to hepatitis C virus infection; additional testing for the hepatitis virus is required to determine acute or active infection.
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Clinical Significance
"Since as many as 90% of commercial intravenous immunoglobulins test positive for hepatitis C antibody, an artifactual positive can result briefly after transfusion. Following the development of sensitive and specific testing for hepatitis B, 90% of posttransfusion hepatitis is now hepatitis C. A gene product (c100) of hepatitis C virus (HCV) was isolated and an assay for anti-HCV developed. The assay detects antibody to presumptive togavirus, which may be an etiologic agent of non-A, non-B hepatitis (which may not be a unitary disease entity).
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