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LIPOPROTEIN (A)
Test Code120188
CPT Codes
83695
Includes
"Quantitation of Lp(a)
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Preferred Specimen
"Serum (preferred) or plasma
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Minimum Volume
0.5 ml
Instructions
"Separate serum or plasma from cells as soon as possible (within two hours).
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Transport Container
"Red-top tube, gel-barrier tube, lavender-top (EDTA) tube, green-top (heparin) tube, or blue-top (citrate) tube
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Transport Temperature
"Refrigerate. Stable refrigerated for 14 days or frozen (if greater than 14 days)
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Specimen Stability
"Stable refrigerated for 14 days or frozen (if greater than 14 days)
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Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
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Grossly hemolyzed, lipemic, or icteric specimens
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Grossly hemolyzed, lipemic, or icteric specimens
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Methodology
"Immunoturbidimetric "
Limitations
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Lp(a) is an independent risk factor for coronary artery disease and cerebral infarction (in white populations) equal to high LDL cholesterol. Serum concentrations are genetically determined. Fifteen percent to 20% of the white population have Lp(a) levels =75 nmol/L and are presumed to be at risk. Race-dependent differences in Lp(a) concentrations are known. Significance of high Lp(a) in nonwhite populations must be evaluated with caution.
The Lp(a) levels in different ethnic populations can vary widely. Africans, or people of African descent, generally have Lp(a) levels higher than Caucasians and Asians, while Native Americans generally have levels lower than Caucasians. This variability of Lp(a) levels by ethnic population requires careful interpretation of results based on a knowledge of the patient and other cardiac risk factors that may be present.3
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Lp(a) is an independent risk factor for coronary artery disease and cerebral infarction (in white populations) equal to high LDL cholesterol. Serum concentrations are genetically determined. Fifteen percent to 20% of the white population have Lp(a) levels =75 nmol/L and are presumed to be at risk. Race-dependent differences in Lp(a) concentrations are known. Significance of high Lp(a) in nonwhite populations must be evaluated with caution.
The Lp(a) levels in different ethnic populations can vary widely. Africans, or people of African descent, generally have Lp(a) levels higher than Caucasians and Asians, while Native Americans generally have levels lower than Caucasians. This variability of Lp(a) levels by ethnic population requires careful interpretation of results based on a knowledge of the patient and other cardiac risk factors that may be present.3
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Reference Range
"<75 nmol/L; values =75 nmol/L may indicate independent risk factor for CHD.
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