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ALPHA-2-ANTIPLASMIN
MessageAvoid warfarin (Coumadin®) therapy for two weeks and heparin therapy for two days prior to the test.
Each factor assay requested must have its own separate aliquot of plasma. If the patient's hematocrit exceeds 55%, the volume of citrate in the collection tube must be adjusted. Refer to Coagulation Collection Procedures for directions.
Each factor assay requested must have its own separate aliquot of plasma. If the patient's hematocrit exceeds 55%, the volume of citrate in the collection tube must be adjusted. Refer to Coagulation Collection Procedures for directions.
Test Code
117739
Alias/See Also
Alpha-2-Antiplasmin
CPT Codes
85410
Preferred Specimen
"Plasma
2 mL"
2 mL"
Minimum Volume
1 mL
Instructions
"Blood should be collected in a blue-top tube containing 3.2% buffered sodium citrate.1 Evacuated collection tubes must be filled to completion to ensure a proper blood-to-anticoagulant ratio.2,3 The sample should be mixed immediately by gentle inversion at least six times to ensure adequate mixing of the anticoagulant with the blood. A discard tube is not required prior to collection of coagulation samples unless the sample is collected using a winged (butterfly) collection system. With a winged blood collection set a discard tube should be drawn first to account for the dead space of the tubing and prevent under-filling of the evacutated tube.4,5 When noncitrate tubes are collected for other tests, collect sterile and nonadditive (red-top) tubes prior to citrate (blue-top) tubes. Any tube containing an alternative anticoagulant should be collected after the blue-top tube. Gel-barrier tubes and serum tubes with clot initiators should also be collected after the citrate tubes. To avoid delays in turnaround time when requesting multiple tests on frozen samples, please submit separate frozen specimens for each test requested.
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Transport Container
"Blue-top (sodium citrate) tube
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Transport Temperature
Frozen
Specimen Stability
Freeze
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
"Tubes improperly filled; improper labeling; clotted specimen; hemolysis; thawed specimen
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Methodology
"Chromogenic "
Clinical Significance
"The most important inhibitor to plasmin, a2-antiplasmin prevents plasmin action on fibrin during fibrinolysis. Decreased levels may lead to easy bruising, epistaxis, hematuria, menorrhagia, hemarthrosis, and bleeding after trauma or surgery.
Congenital deficiency is rare. Acquired deficiency occurs with systemic thrombolytic therapy, acute promyelocytic leukemia, and nephrotic syndrome.
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Congenital deficiency is rare. Acquired deficiency occurs with systemic thrombolytic therapy, acute promyelocytic leukemia, and nephrotic syndrome.
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