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HCV AB W/RFLX TO VERIFICATION
Test Code144065
Alias/See Also
"Anti-HCV Reflex
HCV
Hep C
"
HCV
Hep C
"
CPT Codes
86803 (If reflex testing is performed, additional charges/CPT code(s) may apply.)
Preferred Specimen
"Serum or plasma
1 mL
"
1 mL
"
Instructions
"If tube other than a gel-barrier tube is used, transfer separated serum or plasma to a plastic transport tube.
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Transport Container
"Red-top tube, gel-barrier tube, or lavender-top (EDTA) tube
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Transport Temperature
Refrigerated
Specimen Stability
"
Room temperature
14 days
Refrigerated
14 days
Frozen
14 days
Freeze/thaw cycles
Stable x3
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Room temperature
14 days
Refrigerated
14 days
Frozen
14 days
Freeze/thaw cycles
Stable x3
"
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
"Non-EDTA plasma specimen; PST gel-barrier tube
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Methodology
"Enzyme immunoassay (EIA) reflex to electrochemiluminescence (ECLIA) "
Limitations
"Testing for HCV antibodies is to assess past or present exposure to hepatitis C virus infection; additional testing for the hepatitis virus is required to determine acute or active infection.
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Clinical Significance
"Since as many as 90% of commercial intravenous immunoglobulins test positive for hepatitis C antibody, an artifactual positive can result briefly after transfusion. Following the development of sensitive and specific testing for hepatitis B, 90% of post-transfusion hepatitis is now hepatitis C. A gene product (c100) of hepatitis C virus (HCV) was isolated and an assay for anti-HCV developed. The assay detects antibody to presumptive togavirus which may be an etiologic agent of non-A, non-B hepatitis (which may not be a unitary disease entity).
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