PROTOPORPHYRIN, FEP/ZPP

Test Code

10165

Alias/See Also

"FEP
ZPP
"

CPT Codes
84202

Preferred Specimen

"Whole blood
7 mL"

Minimum Volume

0.2 mL

Instructions

"Mix tube thoroughly to avoid clotting.
"

Transport Container

"Royal blue-top (EDTA) tube or tan-top lead-free tube; submit original tube.
"

Transport Temperature

room temp

Specimen Stability

"Room temperature---14 days
Refrigerated---14 days
Frozen---14 days
Freeze/thaw cycles---Stable x3"

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

"Clotted specimen
"

Methodology
"Fluorometry "

Limitations

"Fluorescent substances in plasma may interfere with hematofluorometer results.2 Skin contamination may lead to false elevations. Both this test and blood lead are needed for full evaluation.
"

Reference Range

"• FEP, blood: environmental exposure: adults: 0-34 µg/dL

• ZPP, blood: environmental exposure: adults: 0-38 µg/dL; occupational exposure: BEI® (sampling time is after one month's exposure): 100 µg/dL1
"

Clinical Significance

"“Free” protoporphyrin is noncomplexed, nonheme protoporphyrin. Lead poisoning is also characterized by elevated plasma and urine d-aminolevulinic acid and increased urinary coproporphyrin. Urinary porphobilinogen and uroporphyrin are normal to slightly increased.3 Free erythrocyte protoporphyrin is a sensitive test for lead toxicity or chronic exposure in adults. Erythrocyte protoporphyrin levels should not be used as a screening test for lead poisoning in children.4 The diagnosis of lead exposure or poisoning includes consideration of environmental exposure, as well as symptoms and abnormal erythrocyte protoporphyrin. This test is not to be used for workplace exposure to lead. If lead testing is required for workplace exposure to lead, please order test 010169.
"

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.