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HNPCC/Lynch Syndrome (MLH1) Sequencing and Deletion/Duplication

Message
Test performed by Arup Laboratories
Diagnostic testing for Lynch syndrome.


Test Code
0051650


CPT Codes
81292; 81294

Preferred Specimen
 Collect: Lavender (EDTA), or yellow (ACD solution A or B).



Minimum Volume
 Transport 3 mL whole blood. (Min: 1 mL)



Transport Temperature
 Storage/Transport Temperature: Refrigerated.


Specimen Stability
 Ambient: 72 hours; Refrigerated: 1 week; Frozen: Unacceptable



Methodology
 Polymerase Chain Reaction/Sequencing/Multiplex Ligation-dependent Probe Amplification.
 Bidirectional sequencing of MLH1 coding regions and intron-exon boundaries; multiplex ligation-dependent probe amplification (MLPA) to detect large MLH1 exonic deletions.



The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.