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Chromosome, Leukemia/Lymphoma
Test Code510999
Alias/See Also
Chromosome Analysis, Hematologic Disorders; Lymphoma
Preferred Specimen
Bone marrow, peripheral blood (>4% blasts required- see Collection), lymph node, spleen, bone core, effusion
Minimum Volume
2ml Bone Marrow or 3ml of Whole Blood
Instructions
The requirement of >4% blasts for blood does not apply to cases of CLL, hairy cell leukemia, and some cases of small cell lymphocytic leukemia (SCLL) or lymphoma which can be B-mitogen stimulated. Submit bone marrow or peripheral blood at room temperature using the Leukemia/Lymphoma Specimen Transport Kit (supplied by LabCorp). Submit lymph node, spleen, or bone core at room temperature using Lymph Node Transport Kit (supplied by LabCorp). Effusions may be sent in same sterile containers. Specimens should arrive in the laboratory within 48 hours of collection. Indicate date and time of collection on the test request form.
Transport Container
Bone marrow or peripheral blood in pediatric green-top (heparin) tube; lymph node, spleen, bone core, CSF or effusion in lymph node transport bottle
Transport Temperature
Room temperature
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Hemolysis; gross contamination; no immature cells; clotted specimen; frozen specimen; fixed specimen; use of improper anticoagulant
Methodology
Short-term cell culture; synchronization; chromosome harvest; G-banding; analysis (20 metaphases) and karyotyping; long-term B-mitogen cultures in some B-cell leukemias
