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ZAP70, IHC without Interpretation
Test Code90242
CPT Codes
88342
Preferred Specimen
Formalin-fixed, paraffin-embedded tissue block submitted in an IHC specimen transport kit
Other Acceptable Specimens
3 unstained, (+) positively charged slides
Transport Temperature
Room temperature
Specimen Stability
Room temperature: Indefinitely
Refrigerated: Indefinitely
Frozen: Unacceptable
Refrigerated: Indefinitely
Frozen: Unacceptable
Methodology
Immunohistochemistry (IHC)
Setup Schedule
Set up: Mon-Fri; Report available: Next day
Clinical Significance
The T-cell kinase ZAP70 is anomalously expressed in the more aggressive, pregerminal center subset of B-cell chronic lymphocytic leukemia and small lymphocytic lymphoma. Expression of ZAP70 by immunohistochemistry is well-correlated with overexpression of ZAP70 by transcript analysis or immunohistochemistry.
Performing Laboratory
Quest Diagnostics Nichols Institute
14225 Newbrook Drive
Chantilly, VA 20153