Mast Cell Tryptase, IHC without Interpretation [40017X]

40017

Formalin-fixed, paraffin-embedded, tissue block

1 block • 3 slides

3 unstained, positively (+) charged slides

IHC Specimen Transport Kit

Room temperature

Room temperature: Indefinitely
Refrigerated: Indefinitely
Frozen: Unacceptable

Set up: Mon-Fri; Report available: 1-4 days

Mast cells contain a number of preformed chemical mediators, such as histamine, chymase, carboxypeptidase, and proteclytic tryptase. A substantial quantity of tryptase is reported to be found in mast cells of skin and lung and suggests this enzyme plays a major role in mast cell mediated events; in vitro studies indicate tryptase can cleave C3 to form C3a anaphylatoxin, inactivate fibrinogen as a coaguable substrate for thrombin, and activate latent collaegnase. Models of allergenic disease in the skin, nose, and lung have indicated elevated tryptase levels. Human mast cell tryptase has been reported to be implicated as a mediator of inflammation. Mast cell degranulation in the gut causes mucus secretion, mucosal edema, increased gut permeability, and may be responsible for some of the symptoms and signs of inflammatory bowel disease.