C4d, IHC without Interpretation

Test Code
90196


CPT Codes
88342

Preferred Specimen
Formalin-fixed, paraffin-embedded block submitted in IHC Specimen Transport Kit


Other Acceptable Specimens
3 unstained, (+) positively charged slides


Transport Container
IHC Specimen Transport Kit


Transport Temperature
Room temperature


Specimen Stability
Room temperature: Indefinitely
Refrigerated: Indefinitely
Frozen: Unacceptable


Methodology
Immunohistochemistry (IHC)

Setup Schedule
Set up: Mon-Fri; Report available: Next day


Clinical Significance
C4d, a stable split product of classical complement activation, is a marker of antibody-mediated acute allograft rejection as well as hyperacute rejection, acute vascular rejection, acute cellular rejection, and borderline rejection. Detection of C4d has been used diagnostically as a predictor of transplant kidney graft survival and for managing acute rejection.


Performing Laboratory
Quest Diagnostics Nichols Institute
14225 Newbrook Drive
Chantilly, VA 20153




The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.