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Metanephrines, Fractionated, LCMSMS, Random Urine [14961X]
Test CodeQ149618
Includes
Metanephrines, Normetanephrines, Total Metanephrines, Creatinine
Preferred Specimen
5 mL random urine (1.5 mL minimum)
Patient Preparation
It is preferable for the patient to be off medications for three days prior to collection. Patient should avoid tobacco, tea, coffee, for three days prior to specimen collection. Common antihypertensives (diuretics, ACE inhibitors, calcium channel blockers, alpha and beta blockers) cause minimal or no interference. Medications which are alpha agonists (Aldomet), alpha blockers (Dibenzyline) should be avoided 18-24 hours prior to specimen collection.
Minimum Volume
1.5 mL
Other Acceptable Specimens
Unpreserved random urine
Instructions
After urine collection, add 25 mL of 6N HCl to maintain a pH below 3. Record patient age on test requisition and urine container.
Transport Temperature
Preserved urine: Room temperature
Unpreserved urine: Frozen
Unpreserved urine: Frozen
Specimen Stability
Preserved urine
Room temperature: 10 days
Refrigerated: 14 days
Frozen: 90 days
Unpreserved urine
Room temperature: Unacceptable
Refrigerated: Unacceptable
Frozen: 30 days
Room temperature: 10 days
Refrigerated: 14 days
Frozen: 90 days
Unpreserved urine
Room temperature: Unacceptable
Refrigerated: Unacceptable
Frozen: 30 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Urine collected with boric acid
Methodology
Chromatography/Mass Spectrometry
FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Setup Schedule
Set up: Mon-Sat; Report available: 2-4 days
Clinical Significance
Useful in the evaluation of pheochromocytoma.
