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Cardiolipin Antibodies (IgA, IgG, IgM)
Test CodeQ7352
Preferred Specimen
1 mL citrated plasma (minimum 0.5 mL)
Alternate specimen: 1 mL serum (minimum 0.5 mL)
Alternate specimen: 1 mL serum (minimum 0.5 mL)
Minimum Volume
0.5 mL
Other Acceptable Specimens
Serum
Transport Container
3.2 sodium citrate (light blue-top tube)
Alternate specimen: No additive (red-top) or SST
Alternate specimen: No additive (red-top) or SST
Transport Temperature
Room temperature
Specimen Stability
Room temperature: 5 days
Refrigerated: 14 days
Frozen: 30 days
Refrigerated: 14 days
Frozen: 30 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gross hemolysis • Grossly lipemic
Methodology
Immunoassay (IA)
Setup Schedule
Set up: Tues-Sat; Report available: 3-5 days
Clinical Significance
Cardiolipin antibodies (CA) are seen in a subgroup of patients with autoimmune disorders, particularly systemic lupus erythematosus (SLE), who are at risk for vascular thrombosis, thrombocytopenia, cerebral infarct and/or recurrent spontaneous abortion. Elevations of CA associated with increased risk have also been seen in idiopathic thrombocytopenic purpura, rheumatoid and psoriatic arthritis, and primary Sjögren's syndrome.
