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Actin (Smooth Muscle) Antibody (IgG)
Test CodeQ15043
Preferred Specimen
0.5 mL serum
Minimum Volume
0.25 mL
Transport Container
No additive serum separator tube or SST
Transport Temperature
Room temperature
Specimen Stability
Room temperature: 14 days
Refrigerated: 14 days
Frozen: 30 days
Refrigerated: 14 days
Frozen: 30 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gross hemolysis • Lipemia • Microbially contaminated serum • Specimens containing heavy, visible particulate
Methodology
Enzyme Linked Immunosorbent Immunoassay (ELISA)
Setup Schedule
Set up: Tues-Sat; Report available: 2-4 days
Clinical Significance
Actin is the major antigen to which smooth muscle antibodies react in autoimmune hepatitis. F-Actin IGG antibodies are found in 52-85% of patients with Autoimmune Hepatitis (AIH) or chronic active hepatitis and in 22% of patients with Primary Biliary Cirrhosis (PBC). Anti-Actin antibodies have been reported in 3-18% of sera from normal healthy controls.
