Rituxan Sensitivity CD20 10981

Test Code

CD20S

Alias/See Also

CD20S

CPT Codes
86356

Preferred Specimen

5 mL whole blood or bone marrow collected in a sodium heparin (green-top) tube or EDTA (lavender-top) tube or ACD solution B (yellow-top) tube

Minimum Volume

1 mL

Other Acceptable Specimens

5 mL buffy coat or fresh (unfixed) tissue • CSF or tissue biopsy or fluid or pleural fluid

Transport Container

Transport Temperature

Room temperature

Specimen Stability

Room temperature: 72 hours
Refrigerated: Unacceptable
Frozen: Unacceptable

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Clotted or fixed sample

Methodology
Flow Cytometry (FC)

FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Setup Schedule

Set up: Daily; Report available: 2-3 days

Reference Range

See Laboratory Report

Clinical Significance

CD20 antigen is expressed on the surface of >90% of B-cell Non-Hodgkin's Lymphomas (NHL). Binding to CD20 antigen is necessary for the antitumor effect of Rituxan®.

Performing Laboratory

Quest Diagnostics Nichols Institute-San Juan Capistrano, CA

33608 Ortega Highway

San Juan Capistrano, CA 92675-2042

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.