Celiac 5y or less w Gliad 36331

CELIAC INFANT

CELIAC INFANT

Tissue Transglutaminase (tTG) Antibody (IgA)
Gliadin (Deamidated) Antibody (IgG, IgA)
IgA (Immunoglobulin A)

If Tissue Transglutaminase (tTG) Antibody (IgA) is Detected (≥15.0 U/mL), then Endomysial Antibody (IgA) Screen with Reflex to Titer will be performed at an additional charge (CPT code(s):86231).
If Endomysial Antibody (IgA) Screen is Positive, then Endomysial Antibody Titer will be performed at an additional charge (CPT code(s): 86231).

If Immunoglobulin A is flagged as low based on age appropriate reference range, or if no age is provided and Immunoglobulin A result is <31 mg/dL, then Tissue Transglutaminase (tTG) Antibody (IgG) will be performed at an additional charge (CPT code(s): 86364).

5 mL serum

1.1 mL

Red

Refrigerated

Room temperature: 72 hours
Refrigerated: 7 days
Frozen: 21 days

Gross hemolysis • Grossly lipemic

Set up and Report available: See individual tests

Tissue Transglutaminase (tTG) Antibody (IgA)

<15.0 U/mL	Antibody not detected
≥15.0 U/mL	Antibody detected

Gliadin (Deamidated) Antibody (IgG)

<15.0 U/mL			Antibody not detected
≥15.0 U/mL			Antibody detected

Gliadin (Deamidated) Antibody (IgA)

<15.0 U/mL			Antibody not detected
≥15.0 U/mL			Antibody detected

IgA (Immunoglobulin A)

Cord Blood		1-3 mg/dL
1-28 days		2-40 mg/dL
1-3 months		3-40 mg/dL
4-6 months		7-47 mg/dL
7-11 months		12-53 mg/dL
1 year		20-73 mg/dL
2 years		20-99 mg/dL
3-5 years		22-140 mg/dL
6-8 years		31-180 mg/dL
9-11 years		33-200 mg/dL
12-16 years		36-220 mg/dL
17-60 years		47-310 mg/dL
≥61 years		70-320 mg/dL

This panel is used to assist in the diagnosis of celiac disease (CD) in children ≤5 years old.
Background: CD is caused by an immune response to gluten in genetically sensitive individuals. Diagnosis begins with serologic testing and is confirmed by biopsy. This panel tests all specimens for tissue transglutaminase (tTG) IgA and gliadin (deamidated) IgA and IgG. Although tTG IgA is generally preferred as a single serological test for CD, it may have reduced sensitivity in young children; including DGP IgA and IgG alongside tTG IgA may increase sensitivity for CD. Specimens positive for tTG IgA are tested for endomysial antibody (IgA), which may increase specificity for CD. This panel also evaluates all specimens for total IgA. A total IgA level below the reference range is suggestive of IgA deficiency and reflexes to tTG IgG, which is generally less sensitive than tTG IgA for CD but is useful in the context of IgA deficiency.