Beta 2 Microglobulin Urine 38994

BETA2MICUA

BETA2MICUA

10 mL urine collected in a Quest Diagnostics Beta-2 Microglobulin Transport Tube (available through Client Supply) and
10 mL unpreserved urine collected in a plastic urine container (for creatinine)

10 mL

Fasting is preferred. Void bladder drink 500 ml water collect urine

URINE

R

⁠⁠⁠⁠⁠⁠⁠Beta-2 urine
Room temperature: 5 days
Refrigerated: 15 days
Frozen: 30 days

Creatinine urine
Room temperature: 7 days
Refrigerated: 7 days
Frozen: 28 days

Specimens received in a non-Beta-2 Microglobulin transport tube with a pH <6 • Any volume other than 10 mL urine in the transport tube • Any specimen with pH <6

Set up: Mon-Sat; Report available: 3 days

B2 Microglobulin/Creatinine Ratio

≤132 mcg/g creat

Creatinine, Random Urine

≤6 Months	2-28 mg/dL
7-11 Months	2-31 mg/dL
1-2 Years	2-110 mg/dL
3-8 Years	2-130 mg/dL
9-12 Years	2-160 mg/dL
>12 Years Male	20-320 mg/dL
>12 Years Female	20-275 mg/dL

Beta-2 Microglobulin (B2M) is a low molecular weight protein that forms the light chain component of the histocompatibility antigen. It is synthesized by all nucleated cell types. It is an integral part of the class I MHC antigens and is present in all body fluids. B2M is filtered through the glomeruli of the kidney and is then reabsorbed and catabolized by the proximal tubular cells. In normal patients only trace amounts of B2M appear in the urine. Elevated urine B2M is seen in tubulo-interstitial disorders. Increased urine B2M is seen in cadmium exposure, diatrizoate, exercise, fever, nephrectomy, semen. There is evidence that monitoring B2M levels in HIV-infected individuals offers an independent predictor of progression to AIDS, leukemia and lymphoma.