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| A B C D E F G H I J K L M N O P Q R S T U V W X Y Z # |
Factor VIII Inhibitor Pn 40083
Test CodeFAC8INHIB
Alias/See Also
FAC8INHIB
CPT Codes
85335
Includes
Factor VIII Inhibitor, Chromogenic Screen
Factor VIII Activity, Clotting
If Factor VIII Inhibitor, Chromogenic Screen is Positive, then Nijmegen Assay will be performed at an additional charge (CPT code(s): 85335).
Factor VIII Activity, Clotting
If Factor VIII Inhibitor, Chromogenic Screen is Positive, then Nijmegen Assay will be performed at an additional charge (CPT code(s): 85335).
Preferred Specimen
2 mL plasma collected in each of two separate 3.2% sodium citrate (light blue-top) tubes
Minimum Volume
1
Instructions
Collect 3 blue tubes spin within 60 min 6ml frozen
Transport Container
BLUE
Transport Temperature
F
Specimen Stability
Room temperature: Unacceptable
Refrigerated: Unacceptable
Frozen: 14 days
Refrigerated: Unacceptable
Frozen: 14 days
Methodology
Chromogenic • Photometric Clot Detection
Setup Schedule
Set up: Sun, Tues, Thurs; Report available: 2-5 days (if reflexed 3-6 days)
Reference Range
| Factor VIII Inhibitor, Chromogenic Screen | Negative |
| Factor VIII Activity, Clotting | 50-180 % normal |
Clinical Significance
The presence of alloantibodies against factor VIII activity is a complication of treatment in hemophilia A, while the presence of autoantibodies may develop spontaneously in patients with acquired Factor VIII-C deficiency. The presence of Factor VIII inhibitor may lead to the neutralization (inactivation) of transfused or endogenous Factor VIII activity. The detection and magnitude of Factor VIII inhibitor is of great importance in the care of these patients. Factor VIII inhibitor Chromogenic assay provides a quick method for the detection of Factor VIII inhibitor with less sample volume.
Performing Laboratory
| Quest Diagnostics Nichols Institute-San Juan Capistrano, CA |
| 33608 Ortega Highway |
| San Juan Capistrano, CA 92675-2042 |
