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A B C D E F G H I J K L M N O P Q R S T U V W X Y Z # |
Celiac Comprehensive Pan 19955
Test CodeCELIAC
Alias/See Also
CELIAC
CPT Codes
83516;82784
Includes
If Tissue Tranglutaminase is positive, Endomysial Ab Screen done if positve an endomysial Ab Titer will be performed. If IgA is lower than reference range TTG IgG will be performed
Preferred Specimen
5 mL serum
Minimum Volume
1
Instructions
Draw one SST and send serum refrigerated
Transport Container
SST
Transport Temperature
R
Specimen Stability
Room temperature: 72 hours
Refrigerated: 7 days
Frozen: 21 days
Refrigerated: 7 days
Frozen: 21 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gross hemolysis • Grossly lipemic
Methodology
Immunoassay (IA) • Immunoturbidimetric
Setup Schedule
Set up: Tues-Sat; Report available: Next day
Reference Range
See individual tests
Clinical Significance
Celiac disease is caused by an immune response to gluten in genetically sensitive individuals. The diagnosis is largely based on a biopsy of the small intestine, but serologic tests also help support a diagnosis and may assist identification of patients who may require biopsy.
Tissue transglutaminase antibodies (tTG, IgA) is a marker with 95% sensitivity and specificity. Total IgA is measured because 2-3% of celiac disease patients are IgA deficient. Because tTG, IgA, and anti-Gliadin IgA tend to decrease in patients on a gluten-free diet, these markers are also used to assess dietary compliance.
The endomysial antibody (EMA, IgA) assay has high specificity for celiac disease and is used to confirm positive anti-tTG results.
Tissue transglutaminase antibodies (tTG, IgA) is a marker with 95% sensitivity and specificity. Total IgA is measured because 2-3% of celiac disease patients are IgA deficient. Because tTG, IgA, and anti-Gliadin IgA tend to decrease in patients on a gluten-free diet, these markers are also used to assess dietary compliance.
The endomysial antibody (EMA, IgA) assay has high specificity for celiac disease and is used to confirm positive anti-tTG results.
Performing Laboratory
Quest Diagnostics Nichols Institute
14225 Newbrook Drive
Chantilly, VA 20153