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Thyroid Stimulating Immuglobin 30551
Test CodeTSI
Alias/See Also
TSI
CPT Codes
84445
Preferred Specimen
1 mL serum
Minimum Volume
1
Instructions
Draw SST and send serum refrigerated.
Transport Container
SST
Transport Temperature
R
Specimen Stability
Room temperature: Unacceptable
Refrigerated: 21 days
Frozen: 60 days
Refrigerated: 21 days
Frozen: 60 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gross hemolysis • Grossly lipemic • Grossly icteric • Plasma
Methodology
In Vitro Bioassay
Setup Schedule
Set up: Mon-Sat; Report available: 3-5 days
Reference Range
<140 % Baseline
Clinical Significance
Graves' disease is a classic form of hyperthyroid disease, affecting approximately 0.4% of the population of the United States. It is caused by IgG immunoglobulins, collectively known as thyroid stimulating immunoglobulins (TSI). Patients who are candidates for antithyroid drug therapy may not respond to this treatment when TSI levels are markedly elevated. The determination of TSI can also assist in predicting hyperthyroidism in neonates, due to placental transmission of the immunoglobulins from a mother with hyperthyroidism.
Performing Laboratory
Quest Diagnostics Nichols Institute
14225 Newbrook Drive
Chantilly, VA 20153
