Beta 2 Microglobulin Serum 852X

Test Code
B2MS

Alias/See Also
B2MS

CPT Codes
82232

Preferred Specimen
1 mL serum

Minimum Volume
1

Instructions
Overnight fasting. Draw one SST and send refrigerated.

Transport Container
SST

Transport Temperature
R

Specimen Stability
Room temperature: 5 days
Refrigerated: 7 days
Frozen: 30 days

Methodology
Nephelometry

Setup Schedule
Setup: Mon-Sat; Report available: 1-3 days

Reference Range
<18 Years Not established
Adults ≤2.51 mg/L


Clinical Significance
Beta-2-microglobulin normally passes through the glomerulus into the proximal tubule where much of it is reabsorbed. Serum levels are therefore an index of glomerular function. When impaired, serum levels rise in inverse ratio to glomerular filtration rate. Increased amounts of beta-2-microglobulin are excreted in several renal disorders, e.g., Balkan nephropathy, heavy metal poisoning and renal tubular disease due to therapeutic agents. Serial levels of beta-2-microglobulin in serum and urine are used to evaluate transplant viability and anticipate rejection. Following a successful graft, serum levels decline toward normal. Increasing serum levels provide an early sign of rejection. Elevated levels are also noted in lymphproliferative disorders, neoplasms (malignant and benign), inflammatory disease, and autoimmune diseases such as systemic lupus erythematosus (SLE) and Sjögren's disease.

Performing Laboratory
Quest Diagnostics Nichols Institute
14225 Newbrook Drive
Chantilly, VA 20153




The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.