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Clomipramine 30013

Test Code
CLOM


Alias/See Also
CLOM


CPT Codes
80335

Includes
Clomipramine, Desmethylclomipramine and Total


Preferred Specimen
3 mL serum collected in a red-top tube (no gel)


Patient Preparation
Collect at steady-state trough concentration. Specimen should be collected >12 hours after dose.

Minimum Volume
1


Other Acceptable Specimens
Plasma collected in: EDTA (lavender-top) tube, sodium heparin (green-top) tube, or lithium heparin (green-top) tube


Instructions
Collect 12 hours after last dose. Trough Concentration


Transport Container
RED


Transport Temperature
R


Specimen Stability
Room temperature: 8 hours
Refrigerated: 5 days
Frozen: 30 days


Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gross hemolysis • Gel barrier/Serum separator tube (SST)


Methodology
Chromatography/Mass Spectrometry

FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Setup Schedule
Set up: Mon-Sat; Report available: Next day


Reference Range
Clomipramine 50-250 mcg/L
Desmethylclomipramine 150-350 mcg/L
Total 200-600 mcg/L


Clinical Significance
Clomipramine and its active metabolite, norclomipramine are antidepressant drugs. Therapeutic drug monitoring is useful to optimize dose and to avoid toxicity.


Performing Laboratory
Quest Diagnostics Nichols Institute
14225 Newbrook Drive
Chantilly, VA 20153



The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.