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Antithrombin III Act. 216

Test Code
AT3


Alias/See Also
AT3


CPT Codes
85300

Preferred Specimen
1 mL frozen platelet-poor plasma collected in 3.2% sodium citrate (light blue-top) tube


Minimum Volume
1


Instructions
Draw one blue top. Send platelet poor plasma one frozen.


Transport Container
BLUE


Transport Temperature
F


Specimen Stability
Room temperature: Unacceptable
Refrigerated: Unacceptable
Frozen: 30 days


Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Hemolysis • Received thawed • Received refrigerated


Methodology
Chromogenic Substrate

Setup Schedule
Set up: Mon-Fri; Report available: Next day


Limitations
Expected impact by therapeutic levels (potential interference depends upon drug concentration): Warfarin: no effect; Heparin (UFH or LMWH): no effect to decrease (UFH may decrease levels physiologically but no assay interference); Dabigatran or Argatroban (Thrombin Inhibitors): may falsely increase; Rivaroxaban or Apixaban (Factor Xa Inhibitors): no effect.


Reference Range
1 day-1 month 41-108 % normal
31 days-2 months 50-120 % normal
3-5 months 73-120 % normal
≥6 months 80-135 % normal


Clinical Significance
Aids in the detection of hypercoagulable states associated with venous thrombotic episodes. May be useful in patients who appear to be hyporesponsive to heparin.


Performing Laboratory
Quest Diagnostics Nichols Institute
14225 Newbrook Drive
Chantilly, VA 20153



The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.