AMIODARONE & METABOLITE 36721X

Test Code
AMIO

Alias/See Also
AMIO

CPT Codes
80299

Includes
Amiodarone and Desethylamiodarone (metabolite)

Preferred Specimen
3 mL serum collected in a red-top tube (no gel)

Minimum Volume
2

Other Acceptable Specimens
Plasma collected in: EDTA (lavender-top), or sodium heparin (green-top), or lithium heparin (green-top) tube

Instructions
Draw one red top tube (no gel) and send serum refrigerated

Transport Container
RED

Transport Temperature
R

Specimen Stability
Room temperature: 48 hours
Refrigerated: 4 days
Frozen: 30 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Hemolysis • Lipemia • Gel barrier/Serum Separator Tube (SST®)

Methodology
High Performance Liquid Chromatography (HPLC) or Liquid Chromatography/Tandem Mass Spectrometry (LC/MS/MS)

FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Setup Schedule
Set up: Tues, Thurs, Sat a.m.; Report available: 2 days

Reference Range
Amiodarone 1.5-2.5 mcg/mL
Desethylamiodarone 1.5-2.5 mcg/mL
  Toxic >2.5 mcg/mL
Toxic effects have been observed at levels as low as 2.0 mcg/mL.

Clinical Significance
Amiodarone is an antiarrythmic drug. Therapeutic drug monitoring is useful to monitor compliance and avoid toxicity.

Performing Laboratory
Quest Diagnostics Nichols Institute
14225 Newbrook Drive
Chantilly, VA 20153



The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.