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A B C D E F G H I J K L M N O P Q R S T U V W X Y Z # |
Protein S Antigen Total 5165
Test CodePROSAG
Alias/See Also
PROSAG
CPT Codes
85305
Preferred Specimen
1 mL frozen citrated plasma collected in a 3.2% sodium citrate (light blue-top) tube
Minimum Volume
1
Instructions
Draw Blue NaCitrate and send plasma frozen
Transport Container
BLUE
Transport Temperature
F
Specimen Stability
Room temperature: Unacceptable
Refrigerated: Unacceptable
Frozen: 30 days
Refrigerated: Unacceptable
Frozen: 30 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Hemolysis • Received room temperature • Received refrigerated • Received thawed
Methodology
Immunoturbidimetric
Setup Schedule
Set up: Tues-Sat; Report available: Next day
Limitations
Expected impact by therapeutic levels (potential interference depends upon drug concentration): Warfarin: no effect to decrease; Heparin (UFH or LMWH): no effect; Dabigatran or Argatroban (Thrombin Inhibitors): no effect; Rivaroxaban or Apixaban (Factor Xa Inhibitors): no effect.
Reference Range
70-140 % normal
Clinical Significance
Protein S (PS) deficiency may be congenital or acquired and is associated with venous thrombosis. Acquired PS deficiency may occur with vitamin K antagonists/deficiency, liver disease, malignancy, consumptive DIC, surgery, trauma, and hepatic immaturity of the newborn. In addition, PS deficiency is physiologic in pregnancy.
Anticoagulant interference: Vitamin K Antagonists (eg. warfarin) will decrease PS antigen levels. PS antigen testing is not impacted by other anticoagulants (heparins, and target specific anticoagulants such as Dabigatran, Argatroban, Rivaroxaban, Apixaban, Edoxaban).
Anticoagulant interference: Vitamin K Antagonists (eg. warfarin) will decrease PS antigen levels. PS antigen testing is not impacted by other anticoagulants (heparins, and target specific anticoagulants such as Dabigatran, Argatroban, Rivaroxaban, Apixaban, Edoxaban).
Performing Laboratory
Quest Diagnostics Nichols Institute
14225 Newbrook Drive
Chantilly, VA 20153