Catecholamines 24-hr Ur 318X

Test Code

CATE UF

Alias/See Also

CATE UF

CPT Codes
82384

Includes

Dopamine, Epinephrine, Norepinephrine, Calculated Total (E + NE)

CPT code 81050 may be added at an additional charge for volume measurement

Preferred Specimen

10 mL of a 24-hour random urine with 25 mL 6N HCl, submitted in a plastic, 24-hour urine container

Patient Preparation
It is preferable for the patient to be off medications for a minimum of 18-24 hours prior to collection. However, common antihypertensives (diuretics, ACE inhibitors, calcium channel blockers, alpha and beta blockers) may cause minimal or no interference.
Patient should avoid tobacco, tea, coffee, and strenuous exercise for 8-12 hours prior to collection.

Minimum Volume

Other Acceptable Specimens

Urine aliquot from a 24-hour urine (unpreserved), with pH ≤6, collected in a plastic, 24-hour urine container

Instructions

Prefer off medications 3 days. 24 hr. urine 25 ml. 6N HCL

Transport Container

UJUG

Transport Temperature

Specimen Stability

Preserved urine
Room temperature: 7 days
Refrigerated: 30 days
Frozen: 49 days

Unpreserved urine
Room temperature: Unacceptable
Refrigerated: 30 days
Frozen: 49 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Preserved urine received refrigerated with pH >3 • Unpreserved urine received frozen with pH >6

Methodology
High Performance Liquid Chromatography (HPLC)

FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Setup Schedule

Set up: Mon-Sat; Report available: 2-4 days

Limitations

Recent surgery, traumatic injury, upright posture, cold, anxiety, pain, clonidine withdrawal, and concurrent acute or chronic illness may produce elevated results.

Reference Range

Epinephrine, 24 hr Urine

3-8 Years	1-7 mcg/24 h
9-12 Years	≤8 mcg/24 h
13-17 Years	≤11 mcg/24 h
>17 Years	2-24 mcg/24 h

Norepinephrine, 24 hr Urine

3-8 Years	5-41 mcg/24 h
9-12 Years	5-50 mcg/24 h
13-17 Years	12-88 mcg/24 h
>17 Years	15-100 mcg/24 h

Calculated Total (E + NE)

3-8 Years	9-51 mcg/24 h
9-12 Years	9-71 mcg/24 h
13-17 Years	13-90 mcg/24 h
>17 Years	26-121 mcg/24 h

Dopamine, 24 hr Urine

3-8 Years	80-378 mcg/24 h
9-12 Years	51-474 mcg/24 h
13-17 Years	51-645 mcg/24 h
>17 Years	52-480 mcg/24 h

Clinical Significance

The three catecholamines (norepinephrine, epinephrine and dopamine) are the principal secretory products of neural tissue. Clinically, the measurement of circulating catecholamines is valuable in the diagnosis of catecholamine secreting tumors associated chiefly with hypertension (pheochromocytomas, neuroblastomas and gangliomas) and with the evaluation of orthostatic hypotension.

Performing Laboratory
Quest Diagnostics Nichols Institute
14225 Newbrook Drive
Chantilly, VA 20153

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.