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C-1-Esterase Inhibitor 298
Test CodeC1EI
Alias/See Also
C1EI
CPT Codes
86160
Preferred Specimen
1 mL serum
Minimum Volume
1
Instructions
Collect 2 red top tubes (no gel) Send 3 ml frozen.
Transport Container
RED
Transport Temperature
F
Specimen Stability
Room temperature: 7 days
Refrigerated: 8 days
Frozen: 1 year
Refrigerated: 8 days
Frozen: 1 year
Methodology
Nephelometry
Setup Schedule
Set up: Mon-Sat p.m.; Report available: Next day
Reference Range
21-39 mg/dL
Clinical Significance
The C1 esterase inhibitor protein is a normal constituent of serum which functions as a serine proteinase inhibitor of the serpin family. The C1 esterase inhibitor inhibits the complement proteases C1r and C1s, as well as the proteases Kallikrein, factor XIa, XIIa and plasmin of the blood clotting system. The concentration of C1 esterase inhibitor protein is reduced to 10-30% of normal in patients with angioedema secondary to C1 esterase inhibitor deficiency (85% of patients with hereditary angioedema (HAE)); in 15% of patients with HAE, the concentrations of the inhibitor protein is normal but function is markedly reduced.
Performing Laboratory
Quest Diagnostics Nichols Institute
14225 Newbrook Drive
Chantilly, VA 20153
