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ADAMTS13 Activity Reflex 145328

Test Code
ADAMTS13


Alias/See Also
ADAMTS13


CPT Codes
85397

Includes
If the ADAMTS13 Activity result is ≤0.30 IU/mL, then ADAMTS13 Inhibitor will be performed at an additional charge (CPT: 85335).


Preferred Specimen
1 mL frozen plasma collected in a 3.2% sodium citrate (light blue-top) tube


Minimum Volume
1


Instructions
Draw light blue (sodium citrate and send platelet-poor plasma frozen with 30 min of drawing specimen


Transport Container
BLUE


Transport Temperature
F


Specimen Stability
Room temperature: Unacceptable
Refrigerated: Unacceptable
Frozen: 21 days


Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gross hemolysis • Grossly lipemic • Grossly icteric


Methodology
Immunoassay (IA)

FDA Status
This test was performed using a kit that has not been cleared or approved by the FDA. The analytical performance characteristics of this test have been determined by Quest Diagnostics. This test should not be used for diagnosis without confirmation by other medically established means.

Setup Schedule
Set up: Sun-Fri; Report available: 2-4 days


Reference Range
ADAMTS13 Activity 0.68-1.63 IU/mL
  ADAMTS13 Inhibitor <0.4 BEU


Clinical Significance
ADAMTS-13 is a zinc metalloprotease that cleaves ultra large vWF multimers. Studies have shown that low levels of ADAMTS-13 activity are associated with thrombotic thrombocytopenic purpura (TTP), a life-threatening hematological condition characterized by a low platelet count, microvascular thrombi, red cell fragmentation, and renal complications. Congenital TTP is a rare inherited disease caused by mutations within the ADAMTS-13 gene, which result in the production of non-functional protein. The acquired form of TTP is an autoimmune-like disorder caused by the development of autoantibodies to ADAMTS-13 that inhibits enzyme activity.


Performing Laboratory
Quest Diagnostics Nichols Institute
14225 Newbrook Drive
Chantilly, VA 20153




The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.