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A B C D E F G H I J K L M N O P Q R S T U V W X Y Z # |
Smooth Muscle Antibody 15043
Test CodeSMO
Alias/See Also
SMO
CPT Codes
83516
Preferred Specimen
0.5 mL serum
Minimum Volume
1
Instructions
Draw one SST and send serum at room temperature.
Transport Container
SST
Transport Temperature
T
Specimen Stability
Room temperature: 14 days
Refrigerated: 14 days
Frozen: 30 days
Refrigerated: 14 days
Frozen: 30 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gross hemolysis • Lipemia • Microbially contaminated serum • Specimens containing heavy, visible particulate
Methodology
Enzyme Linked Immunosorbent Immunoassay (ELISA)
Setup Schedule
Set up: Tues-Sat; Report available: Next day
Reference Range
<20 U | Negative |
≥20 U |
Positive |
Antibodies recognizing actin are the main component of smooth muscle antibodies associated with autoimmune liver disease. Actin antibodies are found in approximately 75% of patients with autoimmune hepatitis (AIH) type 1, approximately 65% of patients with autoimmune cholangitis, approximately 30% of patients with primary biliary cirrhosis, and approximately 2% of healthy people. High values are closely correlated with AIH type 1.
Clinical Significance
Actin is the major antigen to which smooth muscle antibodies react in autoimmune hepatitis. F-Actin IGG antibodies are found in 52-85% of patients with Autoimmune Hepatitis (AIH) or chronic active hepatitis and in 22% of patients with Primary Biliary Cirrhosis (PBC). Anti-Actin antibodies have been reported in 3-18% of sera from normal healthy controls.
Performing Laboratory
Quest Diagnostics Nichols Institute |
14225 Newbrook Drive |
Chantilly, VA 20153 |