A B C D E F G H I J K L M N O P Q R S T U V W X Y Z #

Nicotine and Cotinine Blood 90642

Test Code
NICBLD


Alias/See Also
NICBLD


CPT Codes
80323

Preferred Specimen
1 mL serum collected in a red-top tube (no gel)


Minimum Volume
1


Other Acceptable Specimens
Plasma collected in: EDTA (lavender-top), or (royal blue-top) tube • 4 mL whole blood collected in: EDTA (lavender-top) tube


Instructions
Red top tube (no gel) send 1 ml serum refrig. Rej Hemolysis


Transport Container
RED


Transport Temperature
R


Specimen Stability
Serum and plasma
Room temperature: 72 hours
Refrigerated: 21 days
Frozen: 30 days

Whole blood
Room temperature: 72 hours
Refrigerated: 21 days
Frozen: Unacceptable


Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gross hemolysis • Serum Separator Tube (SST®)


Methodology
Chromatography/Mass Spectrometry

FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Setup Schedule
Set up: Mon-Sat evening; Report available: 3 days


Reference Range
Nicotine, Serum/Plasma
Smoker 2-10 ng/mL
Nonsmoker ≤4 ng/mL

Cotinine, Serum/Plasma
Smoker 16-145 ng/mL
Nonsmoker ≤8 ng/mL


Clinical Significance
This assay is used for the detection of nicotine and cotinine in serum and plasma to determine the tobacco exposure status of the individual. Nicotine has a short half-life of approximately forty minutes; its presence may indicate recent tobacco exposure. Cotinine, the major nicotine metabolite, has a half-life of 24 hours and is detectable for several days after cessation of tobacco exposure.


Performing Laboratory
Quest Diagnostics Nichols Institute
14225 Newbrook Drive
Chantilly, VA 20153




The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.