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| A B C D E F G H I J K L M N O P Q R S T U V W X Y Z # |
IGF Binding Protein 3 34458
Test CodeIGFBINDP3
Alias/See Also
IGFBINDP3
CPT Codes
82397
Preferred Specimen
1 mL serum
Minimum Volume
1
Instructions
Draw one SST and send serum refrigerated
Transport Container
SST
Transport Temperature
R
Specimen Stability
Room temperature: 7 days
Refrigerated: 14 days
Frozen: 1 year
Refrigerated: 14 days
Frozen: 1 year
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gross hemolysis • Grossly lipemic
Methodology
Immunoassay (IA)
Setup Schedule
Set up: Tues-Sat; Report available: Same day
Reference Range
See Laboratory Report
Clinical Significance
Insulin-like growth factor binding proteins bind IGF-I and IGF-II with high affinity but do not bind insulin. Of the 6 distinct IGF binding proteins structurally characterized at this time, IGFBP-3 has been shown to be the major carrier of the IGFs, transporting approximately 95% of circulating IGF-I and IGF-II.
IGFBP-3 is growth hormone (GH) responsive. Thus, levels are high in acromegaly and low in hypopituitarism, and levels increase in GH-deficient children after GH administration. Other causes of short stature that result in reduced IGFBP-3 levels include poorly controlled diabetes. The IGFBP-3 assay is useful in assessing nutritional status, since IGFBP-3 decreases during both caloric and protein restriction.
IGFBP-3 is growth hormone (GH) responsive. Thus, levels are high in acromegaly and low in hypopituitarism, and levels increase in GH-deficient children after GH administration. Other causes of short stature that result in reduced IGFBP-3 levels include poorly controlled diabetes. The IGFBP-3 assay is useful in assessing nutritional status, since IGFBP-3 decreases during both caloric and protein restriction.
Performing Laboratory
Quest Diagnostics Nichols Institute
14225 Newbrook Drive
Chantilly, VA 20153
