A B C D E F G H I J K L M N O P Q R S T U V W X Y Z #

Insulin-like Growth Factor 16293

Test Code
IGF-1


Alias/See Also
IGF-1


CPT Codes
84305

Preferred Specimen
0.5 mL serum


Minimum Volume
1


Instructions
Draw one SST and send serum refrigerated.


Transport Container
SST


Transport Temperature
R


Specimen Stability
Room temperature: 48 hours
Refrigerated: 7 days
Frozen: 60 days


Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Moderate hemolysis


Methodology
Liquid Chromatography/Mass Spectrometry (LC/MS)

FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Setup Schedule
Set up: Daily; Report available: 2-5 days


Reference Range
 Pediatric Male (ng/mL) Female (ng/mL)
<1 Years 14-142 17-185
1-1.9 Years 12-134 15-175
2-2.9 Years 12-135 16-179
3-3.9 Years 30-155 38-214
4-4.9 Years 28-181 34-238
5-5.9 Years 31-214 37-272
6-6.9 Years 38-253 45-316
7-7.9 Years 48-298 58-367
8-8.9 Years 62-347 76-424
9-9.9 Years 80-398 99-483
10-10.9 Years 100-449 125-541
11-11.9 Years 123-497 152-593
12-12.9 Years 146-541 178-636
13-13.9 Years 168-576 200-664
14-14.9 Years 187-599 214-673
15-15.9 Years 201-609 218-659
16-16.9 Years 209-602 208-619
17-17.9 Years 207-576 185-551

Adult (ng/mL)
18-19.9 Years 108-548
20-24.9 Years 83-456
25-29.9 Years 63-373
30-39.9 Years 53-331
40-49.9 Years 52-328
50-59.9 Years 50-317
60-69.9 Years 41-279
70-79.9 Years 34-245
>80 Years 34-246

Z-Score (Male) -2.0 - +2.0 SD
Z-Score (Female) -2.0 - +2.0 SD

Pediatric Tanner Stages See Laboratory Report


Clinical Significance
Insulin-like Growth Factor 1 (IGF-1, or Somatomedin C), a protein involved in stimulating somatic growth, is regulated principally by Growth Hormone (GH) and nutritional intake. IGF-1 is transported in serum by several proteins; this helps maintain relatively high IGF-1 plasma levels and minimizes fluctuations in serum IGF-1 concentrations.
Measuring IGF-1 is useful in several growth-related disorders. Dwarfism caused by deficiency of growth hormone (Hypopituitarism) results in decreased serum levels of IGF-1, while acromegaly (growth hormone excess) results in elevated levels of IGF-1. IGF-1 measurements are also helpful in assessing nutritional status; levels are reduced in undernutrition and restored with a proper diet


Performing Laboratory
Quest Diagnostics Nichols Institute-San Juan Capistrano, CA
33608 Ortega Highway
San Juan Capistrano, CA 92675-2042




The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.