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| A B C D E F G H I J K L M N O P Q R S T U V W X Y Z # |
Adrenocortical Hormone ACTH 211
Test CodeAH
Alias/See Also
AH
CPT Codes
82024
Preferred Specimen
1.5 mL plasma collected in an EDTA (lavender-top) tube
Patient Preparation
Draw specimen between 7 a.m. and 10 a.m. If drawn during any other time, the reference ranges do not apply.
Minimum Volume
1
Other Acceptable Specimens
PPT potassium EDTA (white-top) tube
Instructions
Draw specimen between 7-10 AM in lavender (EDTA) Send plasma frozen
Transport Container
LAV
Transport Temperature
F
Specimen Stability
Room temperature: 16 hours
Refrigerated: 24 hours
Frozen: 28 days
Refrigerated: 24 hours
Frozen: 28 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Received thawed
Methodology
Immunoassay (IA)
Setup Schedule
Set up: Mon-Sat; Report available: Same day
Limitations
With patients receiving more than 5mg/day of biotin, a sample should be taken no sooner than eight hours after previous dose. Patients treated with monoclonal mouse antibodies may have inaccurate results. High titer of antibodies such as streptavidin and ruthenium may cause interference. Due to its correlation with cortisol levels, ACTH concentration is affected by stress. Any single measure may be within the reference range for patients with increased production (Cushing's disease) or minimal production of ACTH.
Reference Range
| <3 Years | Not established |
| 3-17 Years | 9-57 pg/mL |
| ≥18 Years | 6-50 pg/mL |
Clinical Significance
Determination of ACTH is useful in differentiating between primary and secondary adrenocortical hypo- and hyperfunctional disorders: Addison's Disease, Cushing's Syndrome, Adrenal Carcinoma, Ectopic ACTH Syndrome, Nodular Hyperplasia.
Performing Laboratory
Quest Diagnostics Nichols Institute
14225 Newbrook Drive
Chantilly, VA 20153
