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| A B C D E F G H I J K L M N O P Q R S T U V W X Y Z # |
A.phagocytophilum IgG IgM Abs
Test CodeAPHAGOCYT ABS
CPT Codes
86666 (x2)
Includes
If A. phagocytophilum (IgG) is Detected, then A. phagocytophilum (IgG) Titer will be performed at an additional charge (CPT code(s): 86317).
If A. phagocytophilum (IgM) is Detected, then A. phagocytophilum (IgM) Titer will be performed at an additional charge (CPT code(s): 86317).
If A. phagocytophilum (IgM) is Detected, then A. phagocytophilum (IgM) Titer will be performed at an additional charge (CPT code(s): 86317).
Preferred Specimen
1 mL serum
Minimum Volume
0.2 mL
Transport Container
Transport tube
Transport Temperature
Room temperature
Specimen Stability
Room temperature: 7 days
Refrigerated: 14 days
Frozen: 30 days
Refrigerated: 14 days
Frozen: 30 days
Methodology
Immunofluorescence Assay (IFA)
Setup Schedule
Set up: Mon, Wed-Sat; Report available 1-3 days
Reference Range
| A. phagocytophilum Ab (IgG), Screen | Not Detected |
| A. phagocytophilum Ab (IgM), Screen | Not Detected |
| A. phagocytophilum Ab (IgG), Titer | <1:64 titer |
| A. phagocytophilum Ab (IgM), Titer | <1:20 titer |
Clinical Significance
This test is for the detection of IgG and IgM antibodies against Anaplasma phagocytophilum to aid in the diagnosis of Anaplasmosis (human granulocytic anaplasmosis). Anaplasmosis is a tickborne disease caused by transmission of the bacteria via the bite of an infected tick. It is most common in the Northeastern and upper Midwestern United States during warmer months.
Testing for Anaplasmosis is based on a clinical evaluation and risk of tick exposure with consideration to the geographic region. Symptoms may be nonspecific, including headache, fever/chills, malaise, myalgia, gastrointestinal symptoms, and rash (less common). Infection can have similarities with other tickborne illnesses with overlapping vectors, geographic endemicity, and similar clinical signs and symptoms, including Ehrlichia spp, Borrelia burgdorferi (Lyme disease) and Babesia microti.
Negative results can occur early in infection. Nucleic acid amplification tests are the preferred method for diagnosis during acute infection. Seroconversion or a four-fold increase between acute and convalescent sera can be used to support a diagnosis. The presence of IgG alone may indicate past infection, and IgM may persist for many months after infection has resolved. Antibody levels may remain elevated for several years after acute illness. Cross-reactivity between related organisms Anaplasma and Ehrlichia spp, can occur. Therefore, interpretation of serologic results is done in the context of pertinent clinical picture, including timing from symptom onset.
References:
1. Tickborne Diseases of the United States. A Reference Manual for Healthcare Providers, Sixth Edition, 2022. Centers for Disease Control and Prevention.
2. Clinical Testing and Diagnosis for Anaplasmosis. Centers for Disease Control and Prevention. Last updated May 15, 2024. https://www.cdc.gov/anaplasmosis/hcp/diagnosis-testing/index.html
3. Miller, MJ, et al. Guide to Utilization of the Microbiology Laboratory for Diagnosis of Infectious Diseases: 2024 Update by the Infectious Diseases Society of America (IDSA) and the American Society for Microbiology (ASM). Clin Infect Dis. 2024 Mar 5: ciae104.doi: 10.1093/cid/ciae104.
4. Biggs, HM, et al. Diagnosis and Management of Tickborne Rickettsial Diseases: Rocky Mountain Spotted Fever and Other Spotted Fever Group Rickettsioses, Ehrlichioses, and Anaplasmosis - United States. MMWR Recomm Rep. 2016 May 13;65(2):1-44.
Testing for Anaplasmosis is based on a clinical evaluation and risk of tick exposure with consideration to the geographic region. Symptoms may be nonspecific, including headache, fever/chills, malaise, myalgia, gastrointestinal symptoms, and rash (less common). Infection can have similarities with other tickborne illnesses with overlapping vectors, geographic endemicity, and similar clinical signs and symptoms, including Ehrlichia spp, Borrelia burgdorferi (Lyme disease) and Babesia microti.
Negative results can occur early in infection. Nucleic acid amplification tests are the preferred method for diagnosis during acute infection. Seroconversion or a four-fold increase between acute and convalescent sera can be used to support a diagnosis. The presence of IgG alone may indicate past infection, and IgM may persist for many months after infection has resolved. Antibody levels may remain elevated for several years after acute illness. Cross-reactivity between related organisms Anaplasma and Ehrlichia spp, can occur. Therefore, interpretation of serologic results is done in the context of pertinent clinical picture, including timing from symptom onset.
References:
1. Tickborne Diseases of the United States. A Reference Manual for Healthcare Providers, Sixth Edition, 2022. Centers for Disease Control and Prevention.
2. Clinical Testing and Diagnosis for Anaplasmosis. Centers for Disease Control and Prevention. Last updated May 15, 2024. https://www.cdc.gov/anaplasmosis/hcp/diagnosis-testing/index.html
3. Miller, MJ, et al. Guide to Utilization of the Microbiology Laboratory for Diagnosis of Infectious Diseases: 2024 Update by the Infectious Diseases Society of America (IDSA) and the American Society for Microbiology (ASM). Clin Infect Dis. 2024 Mar 5: ciae104.doi: 10.1093/cid/ciae104.
4. Biggs, HM, et al. Diagnosis and Management of Tickborne Rickettsial Diseases: Rocky Mountain Spotted Fever and Other Spotted Fever Group Rickettsioses, Ehrlichioses, and Anaplasmosis - United States. MMWR Recomm Rep. 2016 May 13;65(2):1-44.
Performing Laboratory
| Quest Diagnostics Nichols Institute |
| 14225 Newbrook Drive |
| Chantilly, VA 20153 |
