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Rheumatoid Arth Diag Pn2 91472
Test CodeRF.DIAG
Alias/See Also
RF.DIAG
CPT Codes
86431, 86200, 83520
Includes
Rheumatoid Factor
Cyclic Citrullinated Peptide (CCP) Antibody (IgG)
Mutated Citrullinated Vimentin (MCV) Antibody
Cyclic Citrullinated Peptide (CCP) Antibody (IgG)
Mutated Citrullinated Vimentin (MCV) Antibody
Preferred Specimen
3 mL serum
Minimum Volume
1.5 mL
Instructions
Collect one SST tube, centrifuge and send 3 mL serum frozen.
Transport Container
Transport tube
Transport Temperature
Transport to MMH lab refrigerated and ship to Quest frozen.
Specimen Stability
Room temperature: 4 days
Refrigerated: 7 days
Frozen: 21 days
Refrigerated: 7 days
Frozen: 21 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
See individual assays
Methodology
Enzyme Linked Immunosorbent Immunoassay (ELISA) • Immunoturbidimetric Assay
Setup Schedule
Set up and Report available: See individual assays
Reference Range
Rheumatoid Factor | <14 IU/mL |
CCP Antibody (IgG) | |
Negative | <20 units |
Weak positive | 20-39 units |
Moderate positive | 40-59 units |
Strong positive | >59 units |
MCV Antibody | <20 U/mL |
Clinical Significance
Autoantibody testing has a major role in the diagnosis of RA. This panel includes Rheumatoid factor (RF), anti-cyclic citrullinated peptide (CCP) and anti-mutated citrullinated vimentin (MCV). RF is found in a majority of patients with RA but is not specific for the diagnosis. Anti-CCP antibody is more sensitive and highly specific. RF and anti-CCP are included in the most recent classification criteria for RA. The past several years have seen a search for biomarkers which might increase sensitivity in order to identify the minority of RA patients who are negative for either RF or CCP, especially early in the course of disease. The addition of anti-MCV increases sensitivity for RA when tested together with RF and CCP.
Performing Laboratory
Quest Diagnostics Nichols Institute-San Juan Capistrano, CA |
33608 Ortega Highway |
San Juan Capistrano, CA 92675-2042 |