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A B C D E F G H I J K L M N O P Q R S T U V W X Y Z # |
CSF Alzheimer's Markers
Test CodeAlias/See Also
ADMARK
92433
Alzheimer's Markers CSF
Phospho-Tau CSF
CPT Codes
84393, 82234, 84394
Includes
tTau, CSF
pTau181, CSF
tTau/Abeta42 Ratio
pTau181/Abeta42 Ratio
Preferred Specimen
Minimum Volume
Instructions
Perform lumbar puncture (LP) using gravity drip collection method. Avoid the use of syringes or tubings. Perform lumbar puncture (LP) before noon. Do not use the first 2 mL of CSF for AD Biomarker measurement. Subsequently, collect at least 1.0 mL of CSF directly into the CSF tube 63.614.625 (Sarstedt) for AD biomarker measurements. (Note: The mark on the tube indicates 2.5 mL).
Collect clear (non-hemolytic) CSF in a new CSF tube. Collection of CSF for other purposes can follow thereafter, if required. Do not process the CSF sample before transport to the measuring site (i.e., no mixing/inverting, no tube transfers, no aliquoting, no freezing and normally no centrifugation) until measurement. It is strongly recommended that the sample be kept at 2 to 8°C during transport and storage up to the time of measurement.
Transport Container
Transport Temperature
Specimen Stability
Refrigerated: 14 days
Frozen: 56 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Methodology
Electrochemiluminescence (ECLIA)
Setup Schedule
Reference Range
Beta-Amyloid (1-42), CSF | Not established |
tTau, CSF | Not established |
pTau181, CSF | Not established |
tTau/Abeta42 Ratio | ≤0.28 |
pTau181/Abeta42 Ratio | ≤0.023 |
Clinical Significance
Performing Laboratory
Quest Diagnostics Nichols Institute-San Juan Capistrano, CA |
33608 Ortega Highway |
San Juan Capistrano, CA 92675-2042 |