CSF 14-3-3 Protein (Prion Disease)

Message
Patient Preparation: Cerebrospinal Fluid (CSF) obtained by lumbar puncture. The first 2 mL of CSF that flows from the tap should be discarded. Collect 2 mL of CSF (1 mL minimum), avoiding bloody tap. The sample must be immediately frozen, at least in a -20° C freezer. Freeze within 20 minutes of collection. Store and transport frozen. Required patient information: Please complete and send the National Prion Requisition "Test Request Form", available on the website at National Prion Disease Pathology Surveillance Center with the sample. CSF Test RequisitionImmediate Specimen Processing: Freeze within 20 minutes of collection. Ambulatory Transport Temperature to Inova Central Lab: FrozenSpecimen Stability: Indefinitely


Test Code
LAB17688 1433P


Alias/See Also
1433P


CPT Codes
0035U| 83520| 84394

Includes
Patient Preparation: The patient must be 12 years of age or older.This test includes the following components: 14-3-3 GAMMA, T-tau protein, and RT-QuIC@BKRCERMSGREFRESH(2302793)@ @BKRCERMSGREFRESH(2302794)@


Instructions
Processing Instructions: Specimen must remain frozen. Ship to Quest frozen. Required patient information: Please complete and send the National Prion Requisition "Test Request Form", available on the website at National Prion Disease Pathology Surveillance Center with the sample.CSF Test RequisitionPreferred Testing Volume: 2 mL CSFMinimum Testing Volume: 1 mL CSF Transport Temperature: Frozen Stability: Ambient: UnacceptableRefrigerated : UnacceptableFrozen: Indefinitely Causes for Rejection: Bloody and insufficient sample quantity. Samples that are colored or contain blood cannot be performed for RT-QuIC and 14-3-3 GAMMA.Performing Lab: Performing Lab: National Prion Disease Pathology Surveillance Center


Report Available
9-Days


Clinical Significance
1230171455



Last Updated: May 18, 2026


The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.