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Plasma Renin Activity
MessageThis test was developed and its performance characteristics have been determined by Quest Diagnostics Nichols Institute. It has not been cleared or approved by the U.S. Food and Drug Administration. The FDA has determined that such clearance or approval is not necessary. Performance characteristics refer to the analytical performance of the test.
Test Code
REN
CPT Codes
84244
Preferred Specimen
3 mL plasma (0.4 mL minimum).
Instructions
Centrifuge and separate blood at room temperature. Avoid refrigerated temperatures. When submitting catheterization studies, it is recommended that the referring laboratory retain a portion of each sample. Patient should refrain from taking medications, preferably 3 weeks prior to draw. Patient should be ambulatory for 30 minutes prior to draw. Patient should be on a moderate sodium diet during collection.
Transport Container
EDTA (lavender-top)
Transport Temperature
Frozen, stable 6 months
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Received refrigerated
Methodology
Angiotensin I Generation, Radioimmunoassay
Reference Range
Supine Upright
Adults (a.m. and p.m.) 0.3-3.0 ng/mL/hr 0.4-8.8 ng/mL/hr
Renovascular Hypertension >10 ng/mL/hr
Pediatric
Premature Infants
1st Week of Life 34.0 ng/mL/hr or Less
2-4 Weeks 147.9 ng/mL/hr or Less
Full Term Neonates 26.0 ng/mL/hr or Less
Supine Upright
(ng/mL/hr) (ng/mL/hr)
3-12 Months 15.0 or Less
1-3 Years 10.0 or Less
4-6 Years 7.5 or Less 15.0 or less
7-9 Years 5.9 or Less 17.0 or less
10-12 Years 5.3 or Less 16.0 or less
13-15 Years 4.4 or Less 16.0 or less
Pediatric data from J Pediatrics (1976) 89:256, Pediat Res (1979) 13:817, and Eur J Pediatr (1994) 153:284.
Adults (a.m. and p.m.) 0.3-3.0 ng/mL/hr 0.4-8.8 ng/mL/hr
Renovascular Hypertension >10 ng/mL/hr
Pediatric
Premature Infants
1st Week of Life 34.0 ng/mL/hr or Less
2-4 Weeks 147.9 ng/mL/hr or Less
Full Term Neonates 26.0 ng/mL/hr or Less
Supine Upright
(ng/mL/hr) (ng/mL/hr)
3-12 Months 15.0 or Less
1-3 Years 10.0 or Less
4-6 Years 7.5 or Less 15.0 or less
7-9 Years 5.9 or Less 17.0 or less
10-12 Years 5.3 or Less 16.0 or less
13-15 Years 4.4 or Less 16.0 or less
Pediatric data from J Pediatrics (1976) 89:256, Pediat Res (1979) 13:817, and Eur J Pediatr (1994) 153:284.
Clinical Significance
The measurement of plasma renin activity (PRA) is useful in evaluating hypertension. A normal or high PRA rules out primary aldosteronism, whereas a normal or low PRA helps rule out renal hypertension. Additionally, an elevated PRA may indicate renovascular hypertension due to renal artery stenosis.
