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Prothrombin Gene Analysis
Test CodePTNGM
CPT Codes
83891; 83892; 83896 (x2); 83908; 83912
Preferred Specimen
5 mL whole blood (3 mL minimum)
Transport Container
Lavender Top EDTA Tube
Transport Temperature
Room temperature, stable 8 days
Methodology
Invader Assay/Signal Amplification
Clinical Significance
The Prothrombin (Factor II) 20210G>A Mutation is associated with elevated prothrombin concentrations and is the second most common inherited risk factor for venous thrombosis. Risk is amplified if combined with Factor V Leiden mutation or other risk factors such as oral contraceptive use.