HPV Genotypes 16 and 18, Cervical

Test Code

HPVG

CPT Codes
87625

Preferred Specimen

ThinPrep®: 3 mL of PreservCyt® fluid, or
SurePath™: 2 mL of SurePath™ fluid

Minimum Volume

ThinPrep®: 1.5 mL
SurePath™:1 mL

Instructions

Collect the sample as usual according to the manufacturer's instructions.

Note: SurePath™ pellet is no longer acceptable

Transport Temperature

Room temperature

Specimen Stability

ThinPrep®
Room temperature: 90 days
Refrigerated: 90 days
Frozen: Unacceptable

SurePath™
Room Temperature: 28 days
Refrigerated: 90 days
Frozen: Unacceptable

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Cervical swabs in Digene® HC cervical sampler • SurePath™ vial without cervical brush/broom • Swabs • SurePath™ pellet • Samples treated with Acetic Acid • Vaginal sources

Methodology
Real-Time Polymerase Chain Reaction

Setup Schedule

Set up: Tues-Sat; Report available: 1-3 days

Reference Range

HPV 16	Not detected
HPV 18	Not detected

Clinical Significance

Persistent infection with high-risk HPV types increases a woman's risk for progression to dysplasia or cervical cancer. The rate of progression or degree of risk depends on the HPV type. Of all various high-risk types, HPV Types 16 and 18 cause more than 60-65% of cervical cancers. This test will identify the presence or absence of HPV Type 16 DNA and/or Type 18 DNA. Knowledge of the HPV genotype will help physicians diagnose the type of HPV infection and its risk of developing into dysplasia or cervical cancer.

Performing Laboratory
Quest Diagnostics Nichols Institute
14225 Newbrook Drive
Chantilly, VA 20153

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.