Vitamin E (Tocopherol)

Test Code
VITE

CPT Codes
84446

Includes
Alpha-Tocopherol, Beta-Gamma-Tocopherol

Preferred Specimen
2 mL serum - protect from light

Minimum Volume
0.5 mL

Instructions
Centrifuge within 1 hour of collection. Pour serum sample into a plastic, amber tube. If an amber tube is not available, wrap tube in aluminum foil to protect from light.

Transport Container
Plastic screw-cap vial protected from light

Transport Temperature
Refrigerated (cold packs)

Specimen Stability
Room temperature: 24 hours
Refrigerated: 7 days
Frozen: 1 Year

Methodology
High Performance Liquid Chromatography (HPLC)

Reference Range
Alpha-Tocopherol  
Adult 5.7-19.9 mg/L
Pediatric  
  Term Infants (Cord Blood) 1.8-5.8 mg/L
  4 Months-1 Year ≤9.1 mg/L
  1-2 Years 2.9-16.6 mg/L
  3-5 Years 5.5-11.8 mg/L
  6-8 Years 4.6-14.8 mg/L
  9-11 Years 6.2-14.3 mg/L
  12-17 Years 3.7-12.4 mg/L
Levels of alpha-tocopherol <5 mg/L are consistent with Vitamin E deficiency in adults
Beta-Gamma-Tocopherol  
Adult ≤4.3 mg/L
Pediatric 3-17 Years 0.5-3.8 mg/L


Clinical Significance
Deficiency of vitamin E may cause extensive neuropathy in young children and, in addition, is suspect as a possible cause of motor and sensory neuropathy in older children and in adults. One likely cause of vitamin E deficiency is intestinal malabsorption, resulting from bowel disease, pancreatic disease, or chronic cholestasis. Other causes of malabsorption of vitamin E include celiac disease, cystic fibrosis, and intestinal lymphangiectasia.

Performing Laboratory
Quest Diagnostics Nichols Institute
14225 Newbrook Drive
Chantilly, VA 20153



The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.