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Valproic Acid, FreeTest Code
3 mL serum collected in a red-top tube (no gel)
Other Acceptable Specimens
Serum collected in no additive (royal blue-top) tube • Plasma collected in an EDTA (lavender-top), or EDTA (royal blue-top) tube
Do not use gel barrier tubes. Centrifuge and immediately separate serum or plasma specimens from the cells into clean, plastic, screw-cap vial(s). Do not use serum separator tubes. Submission of a serum separator tube will result in cancellation.
Plastic screw-cap vial(s)
Refrigerated (cold packs)
Room temperature: 48 hours
Refrigerated: 7 days
Frozen: 60 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Serum separator tube (SST®)
Fluorescence Polarization Immunoassay (FPIA)
Detection limit 2.0 mg/L
Note: Nonlinear drug binding properties result in the fraction of free valproic acid increasing as total drug increases. The free fraction may range from 5% to 25% for the total drug range of 30-160 mg/L.
Valproic acid is a broad spectrum anticonvulsant for the treatment of absence seizures. It is effective in the management of generalized tonic-econic and myoconic seizures, as well as grand mal and petit mal.
Quest Diagnostics Nichols Institute
14225 Newbrook Drive
Chantilly, VA 20153