Estrone

Test Code

ESTR

CPT Codes
82679

Preferred Specimen

0.5 mL serum collected in a red-top tube (no gel)

Minimum Volume

0.25 mL

Instructions

Specify age and sex on test requisition

Transport Temperature

Refrigerated (cold packs)

Specimen Stability

Room temperature: 72 hours
Refrigerated: 30 days
Frozen -20° C: 30 days
Frozen -70° C: 1 year

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Serum separator tube (SST) • Gross hemolysis

Methodology
Chromatography/Mass Spectrometry

FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Setup Schedule

Set up: Daily; Report available: 2-5 days

Reference Range

Adult
Male	≤68 pg/mL
Female
Follicular Phase	10-138 pg/mL
Luteal Phase	16-173 pg/mL
Postmenopausal Phase	≤65 pg/mL

Pediatric

Age	Male (pg/mL)	Female (pg/mL)
Pre-pubertal (1-9 years)	<10	≤34
10-11 years	≤12	≤72
12-14 years	≤28	≤75
15-17 years	≤64	≤188

Clinical Significance

Estrone is primarily derived from metabolism of androstenedione in peripheral tissues, especially adipose tissues. Individuals with obesity have increased conversion of androstenedione to Estrone leading to higher concentrations. In addition, an increase in the ratio of Estrone to Estradiol may be useful in assessing menopause in women.

Performing Laboratory

Quest Diagnostics Nichols Institute-San Juan Capistrano, CA

33608 Ortega Highway

San Juan Capistrano, CA 92675-2042

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.