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FISH, Products of Conception (POC) Panel
Test Code14820
CPT Codes
88274 (x3), 88271 (x7)
Physician Attestation of Informed Consent
This germline genetic test requires physician attestation that patient consent has been received if ordering medical facility is located in AK, DE, FL, GA, IA, MA, MN, NV, NJ, NY, OR, SD or VT or test is performed in MA.
Includes
Chromosomes 13, 16, 18, 21, 22, X, Y
Preferred Specimen
5 x 5 mm tissue collected in Hanks', Ringer's solution or culture medium with antibiotics
Minimum Volume
2 x 3 mm
Other Acceptable Specimens
2 x 3 mm tissue in a formalin-fixed, paraffin-embedded tissue block
Instructions
Specimen viability decreases during transit. Send specimen to testing laboratory for viability determination. Do not reject.
Please note: In the event of a growth failure or formalin-fixed tissues that result in no routine cytogenetic analysis, FISH can be attempted
Please note: In the event of a growth failure or formalin-fixed tissues that result in no routine cytogenetic analysis, FISH can be attempted
Transport Temperature
Room temperature
Specimen Stability
Room temperature: Preferred
Refrigerated: Acceptable
Frozen: Unacceptable
Refrigerated: Acceptable
Frozen: Unacceptable
Methodology
Fluorescence in situ Hybridization (FISH)
FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Setup Schedule
Monday-Sunday Morning Report available: 7 Days
Limitations
The FISH test is limited in that it only counts the number of each of the included chromosomes (13, 16, 18, 21, 22, X, and Y). This assay will not detect chromosome mosaicism, duplications, deletions, or structural rearrangements and does not identify all birth and/or developmental abnormalities.
Reference Range
See Laboratory Report
Clinical Significance
Approximately 15% of all clinically recognized pregnancies are spontaneously aborted (SAB). A significant number of these samples in culture do not yield metaphase cells to perform cytogenetic studies. Using FISH probes will allow for detecting common cytogenetic abnormalities.
Performing Laboratory
Quest Diagnostics Nichols Institute
14225 Newbrook Dr
Chantilly, VA 20153