CLL FISH PANEL

Test Code

BCELLCLL

Alias/See Also

QUEST TC# 16864
FISH B CELL CLL PANEL

Includes

Probes: 6q- [SEC63 (6q21), MYB (6q23)] | ATM (11q22.3) | p53 (17p13.1) | Trisomy 12 (Cen 12) | 13q-/-13 (13q14, 13q34) | CCND1/IgH t(11;14) | Probes may be ordered separately (except 12 and 13 are tested together, and ATM is tested with p53).

Disease(s): Chronic lymphocytic leukemia

Note: This test was previously called CLL FISH Panel (non-New York). It is now New York state-approved and available to all clients.

Preferred Specimen

Bone Marrow Aspirate: 1-2 mL sodium heparin tube. EDTA tube is acceptable.

Peripheral Blood: 2-5 mL sodium heparin tube. EDTA tube is acceptable.

Fresh, Unfixed Tissue: Tissue in RPMI.

Fluids: Equal parts RPMI to specimen volume

Paraffin Block: Send paraffin block. Also send circled H&E slide for tech-only (required). Note: Not approved for NYS samples.

Cut Slides: H&E slide (required) plus 4 unstained slides cut at 4-5 microns. Circle H&E slide for tech-only. Note: Not approved for NYS samples.

Note: Please exclude biopsy needles, blades, and other foreign objects from transport tubes. These can compromise specimen viability and yield, and create hazards for employees.

Transport Temperature

Use cold pack for transport, making sure cold pack is not in direct contact with specimen.

Methodology
FISH

Report Available

3-5 days

Clinical Significance

The CLL FISH panel is used for the detection of chromosome aberrations observed in chronic lymphocytic leukemia/small lymphocytic lymphoma, which are useful in prognosis and prediction of time to treatment in CLL patients when used in combination with other clinical and diagnostic findings. CCND1/IgH is used to rule out mantle cell leukemia/lymphoma.

Performing Laboratory
NEO GENOMICS

Last Updated: September 13, 2022

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.