Chromosome Analysis, Hematologic Malignancy

Test Code
14600


CPT Codes
88237, 88264

Preferred Specimen
10 mL whole blood or 3 mL bone marrow collected in a sodium heparin (green-top) tube
Infants: 2-3 mL whole blood collected in a pediatric (3 mL) vacutainer


Minimum Volume
1 mL


Other Acceptable Specimens
Bone marrow or whole blood collected in: sodium heparin (royal blue-top), or sodium heparin lead-free (tan-top) tubes


Instructions
Clinical history and reason for referral are required with test order. Previous bone marrow transplant or therapy information, if applicable, should be provided with test order.

Bone marrow: 3 mL or whole blood 10 mL, must contain 10% less mature myelocytes, pros, or blasts green vacutainer only. Infants 2-3 mL (in pediatric 3 mL vacutainer), must contain 10% myelocytes, pros or blasts. Ship at room temperature. Bone marrow transport medium is available upon request.

Note: See the "cytogenetics" section of the specimen collection guide for additional information. Other vacutainer tubes containing sodium heparin are acceptable.

This test may be replaced by one of the following if the completed test cannot be performed from the submitted specimen: a Tissue Culture for Hematologic Disorder code; or with a Cytogenetics Communication, if a communication is required.


Transport Temperature
Room temperature


Specimen Stability
72 HOURS


Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Received frozen


Methodology
Culture • Karyotype • Microscopy

Setup Schedule
Performing Laboratory;
Quest Diagnostics Nichols Institute
14225 Newbrook Drive
Chantilly, VA 20153


Reference Range
See Laboratory Report


Clinical Significance
Cytogenetics of hematologic disorders attempts to define and interpret chromosomal aberrations that occur in neoplastic cells associated with leukemia, lymphoma and other hematologic malignancies. Chromosome abnormalities in cancer cells of patients with malignant hematologic disorders including acute and chronic myeloid and lymphoid leukemias, myelodysplastic and myeloproliferative disorders, lymphomas and unexplained anemias may correlate with the diagnosis, prognosis, treatment and etiology of disease.


Performing Laboratory
Quest Diagnostics Nichols Institute
14225 Newbrook Drive
Chantilly, VA 20153


Last Updated: December 17, 2020


The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.