Histone Antibodies

Test Code

ANTIHIST

Quest Code

37056

Alias/See Also

ANTIHIST
Histone Ab

CPT Codes
83516

Preferred Specimen

1 mL serum

Patient Preparation
Overnight fasting preferred

Minimum Volume

0.3 mL

Transport Temperature

Refrigerated (cold packs)

Specimen Stability

Room temperature: 24 hours
Refrigerated: 14 days
Frozen: 30 days

Methodology
Enzyme Immunoassay (EIA)

Setup Schedule

Set up: Tues-Sat; Report available: Next day

Reference Range

Value	Explanation of Results
<1.0	Negative
1.0-1.5	Weak Positive
1.6-2.5	Moderate Positive
>2.5	Strong Positive

Clinical Significance

Histone antibody is present in 80-95% of patients with drug-induced Systemic Lupus Erythematosus (SLE), 20-50% of patients with idiopathic SLE, and infrequently in patients with other autoimmune connective tissue diseases.

Performing Laboratory
Quest Diagnostics Nichols Institute
14225 Newbrook Drive
Chantilly, VA 20153

Last Updated: September 27, 2019

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.