Estradiol, Ultrasensitive, LC/MS

Test Code
Estradiol, Ultrasensitive, LC/MS-MISC


Quest Code
30289


CPT Codes
82670

Preferred Specimen
0.5 mL serum collected in a red-top tube (no gel)


Minimum Volume
0.2 mL


Instructions
Specify age and sex on test request form


Transport Temperature
Refrigerated (cold packs)


Specimen Stability
Room temperature: 24 hours
Refrigerated: 7 days
Frozen: 28 days


Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Serum separator tube (SST) • Grossly icteric


Methodology
Chromatography/Mass Spectrometry

FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Setup Schedule
Set up: Sun-Fri; Report available: 3-6 days


Reference Range
Adult Reference Ranges for Estradiol, Ultrasensitive
Males≤29 pg/mL
Females 
  Follicular Phase39-375 pg/mL
  Luteal Phase48-440 pg/mL
  Postmenopausal Phase≤10 pg/mL

Pediatric Reference Ranges for Estradiol, Ultrasensitive
AgeMales
(pg/mL)
Females
(pg/mL)
Pre-pubertal
  <1 yearNot EstablishedNot Established
  1-9 years≤4≤16
  
10-11 years≤12≤65
12-14 years≤24≤142
15-17 years≤31≤283


Clinical Significance
Diagnostic applications of estradiol assays include assessment of ovarian function in a wide variety of situations (menstrual disorders, precocious or delayed puberty, assisted reproduction protocols). For men, estradiol measurement may be useful in the evaluation of gynecomastia.


Performing Laboratory
Quest Diagnostics Nichols Institute-San Juan Capistrano, CA
33608 Ortega Highway
San Juan Capistrano, CA 92675-2042



Last Updated: February 25, 2021


The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.